Peroxisome proliferator activating receptor-γ and the podocyte
نویسندگان
چکیده
منابع مشابه
Telmisartan exerts antiatherosclerotic effects by activating peroxisome proliferator-activated receptor-γ in macrophages.
OBJECTIVE Telmisartan, an angiotensin type I receptor blocker (ARB), protects against the progression of atherosclerosis. Here, we investigated the molecular basis of the antiatherosclerotic effects of telmisartan in macrophages and apolipoprotein E-deficient mice. METHODS AND RESULTS In macrophages, telmisartan increased peroxisome proliferator-activated receptor-γ (PPARγ) activity and PPAR ...
متن کاملEffect of peroxisome proliferator-activated receptor γ on inflammatory markers
Introduction In a recent study published in “ARYA atherosclerosis,” Pourmoghaddas et al. reported that administration of pioglitzone in non-diabetic patients with metabolic syndrome had no positive effect on inflammatory markers including high sensitive C-reactive protein, interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α).1 Peroxisome proliferator-activated receptors (PPARs) are ligan...
متن کاملPeroxisome proliferator-activated receptor-γ protects against vascular aging.
Vascular disease occurs commonly during aging. Carotid artery and cerebrovascular disease are major causes of stroke and contributors to dementia. Recent evidence suggests that peroxisome proliferator-activated receptor-γ (PPARγ) may play a protective role in the vasculature, but the potential importance of PPARγ in vascular aging is unknown. To examine the hypothesis that PPARγ normally protec...
متن کاملRole of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nucl...
متن کاملMode of peroxisome proliferator-activated receptor γ activation by luteolin.
The peroxisome proliferator-activated receptor γ (PPARγ) is a target for treatment of type II diabetes and other conditions. PPARγ full agonists, such as thiazolidinediones (TZDs), are effective insulin sensitizers and anti-inflammatory agents, but their use is limited by adverse side effects. Luteolin is a flavonoid with anti-inflammatory actions that binds PPARγ but, unlike TZDs, does not pro...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2016
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfw320